31 July 2016 to 5 August 2016
Gaylord Hotel and Conference Center
US/Eastern timezone

Imaging of biologic samples using betatron radiation

2 Aug 2016, 10:45
15m
Woodrow Wilson B (Gaylord Hotel)

Woodrow Wilson B

Gaylord Hotel

Oral Working Group 7 WG7

Speaker

Dr. Nelson Lopes (Imperial College London)

Abstract

Betatron radiation from a laser-wakefield accelerator driven by a 10 J laser pulse was used to produce high-quality x-ray images of biological and material samples, as well as images of laser undated shocks in solids. We present the evolution of the radiation source in the last two years as well as adequate methods to use it in biological imaging.

Summary

A laser wakefield accelerator, driven by $10 \;J$, $40 \;fs$, NIR laser pulses focused in a gas target $2 \; cm$ long, was optimised to produce sharp x-ray images that can be used to produce 2D and 3D imaging of different types of samples including biological samples and laser induced shocks in solids. The betatron x-ray beam with a critical energy of $15-30 \; keV$, a divergence of $12 \; mrad$ (FWHM) and a brightness up to $4.5 \times 10^7$ photons (with energy $> 10 \;keV$) / $ mm^{2}$ (at 1 meter from source), per shot, is produced when about 50% of the laser energy is focused in the gas target on a gaussian spot of $40 \; \mu$m (FWHM) by a $F/40$ focusing optic. High-quality few-micron resolution lenseless imaging in both absorption and phase contrast were obtained for samples with size up to $1 cm$, limited by the available laboratory space.
We combined new low-light image treatment techniques with this radiation source to demonstrate its potential to be used in a fast turnaround low-dose phase contrast 2D and 3D medical imaging with future $10 \; Hz$, $100\;TW$ lasers.

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Primary author

Dr. Nelson Lopes (Imperial College London)

Co-authors

Prof. A. E. Dangor (Imperial College London) Dr. Adrian Lim (Imperial College London) Dr. Andi Jin (Imperial College London) Dr. Chris Hooker (Rutherford Appleton Laboratory, Chilton, UK) Dr. Christopher Spindloe (Rutherford Appleton Laboratory, Chilton, UK) Dr. Christos Kamperidis (Imperial College London) Dr. Daniel Eakins (Imperial College London) Dr. Daniel Symes (Rutherford Appleton Laboratory, Chilton, UK) Dr. David Chapman (Imperial College London) Prof. Dominic Morris (MRC Mammalian Genetics Unit, Harwell, UK) Prof. Eric Aboagye (Imperial college London) Dr. Henrik Westerberg (MRC Mammalian Genetics Unit, Harwell, UK) J. Sanderson (MRC Mammalian Genetics Unit, Harwell, UK) Dr. Jason Cole (Imperial college London) Dr. Jonathan Wood (Imperial College London) Dr. Kristjan Poder (Imperial College London) Dr. Laura Kenny (Imperial College London) Dr. Lydia Teboul (MRC Mammalian Genetics Unit, Harwell, UK) Dr. Manveer Sroya (Imperial College London) Prof. Mathias Winkler (Imperial College London) Dr. Michael Rutherford (Imperial College London) Dr. Nicola Booth (Rutherford Appleton Laboratory, Chilton, UK) Dr. Nyethane Ngo (Imperial College London) Dr. Pattathil Rajeev (Rutherford Appleton Laboratory, Chilton, UK) Prof. Paul Abel (Imperial College London) Dr. Peta Foster (Rutherford Appleton Laboratory, Chilton, UK) Dr. Quang-de Nguyen (Imperial College London) Prof. R. C. Coombes (Imperial College London) Dr. Richard Abel (Imperial College London) Dr. Rob Clark (Rutherford Appleton Laboratory, Chilton, UK) Dr. Saleh Alatabi (Imperial College London) Prof. Sami Shousha (Imperial College London) Dr. Sara Johnson (MRC Mammalian Genetics Unit, Harwell, UK) Mr. Stephen Ball (Imperial College London) Dr. Steve Hawkes (Rutherford Appleton Laboratory, Chilton, UK) Dr. Stuart Mangles (Imperial College London) Dr. Thomas White (Imperial College London) Prof. Zulfikar Najmudin (Imperial College London)

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